Idebenone – A Powerful Antioxidant
It provides better and greater value than CoQ10 for mitochondrial support, cognitive enhancement and energy.
√ Helps to Boost Brain Health and Mental Function
√ Potent Anti-Oxidant for Healthy Living
√ May Support ATP Production & Energy Levels
What is Idebenone?
Idebenone is a synthetic analog of Coenzyme Q10 (CoQ10) an essential biochemical. Co Q10 is an important antioxidant BUT Idebenone is a more powerful antioxidant than Co Q10 plus some studies have shown it as a free radical quencher within brain cells up to 100 times more effective than Vitamin E or Vinpocetine.
Further studies using brain cells have shown the ability of Idebenone to enhance brain structure and function plus its enhancement of serotonin production and the cellular uptake of the amino-acid precursor tyrosine and cholinergic nerve function, which helps learning even under low oxygen conditions.
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Benefits of Idebenone
- Idebenone is a more powerful antioxidant than Co Q10 and 100 times more effective than Vitamin E or Vinpocetine.
- Idebenone enhances a key part of memory formation and consolidation and restores glucose utilization (brain fuel) and ATP (energy) production in poor brain blood flow conditions.
- Idebenone has been shown to enhance general cerebral metabolism, lessen the damage from strokes and it is being used to treat Alzheimer’s and other dementias.
- Idebenone protects organs in many ways working against low oxygen levels and poor blood flow damage whilst enhancing ATP (energy) production.
Idebenone has a synergy with other anti-aging products such as Hydergine, Piracetam (and its analogues), Deprenyl and GH3. In this situation it is usual for the dosage to be just one 45mg tablet a day, especially if taken regularly on a long-term basis. Because Idebenone is fat soluble, it is best taken with a fat rich meal or with lipid-absorption enhancing products like lecithin or phosphatidyl choline.
Consult a medical professional for the appropriate dosage recommendations as Idebenone is useful for many different conditions including:
- Stroke – victims wishing to improve memory, emotional or speech disturbances
- Alzheimer’s and cerebrovascular dementia
- Pre major surgery – especially brain, heart, liver or kidney
- Ischemic heart disease
- Congestive heart failure
- Multiple sclerosis
Idebenone – Uses and Effectiveness
Co Q10 is an important part of the “Electron Transport Chain” within the “power plants” of the cell – mitochondria. Most of the oxygen we breathe is used inside the electron transport chain to produce ATP (energy) that powers almost all the activity of our cells and bodies. Without CoQ10, or a good substitute, human life quickly ends.
If blood flow is seriously reduced to any part of the body cellular/ mitochondrial oxygen levels quickly drop in the affected region. Some examples of this are heart attack, stroke, trauma or shock. But as oxygen is much more soluble in the lipid (fatty) zones of cell membrane, (compared to the watery compartments of the cell), there is still sufficient oxygen remaining in the membranes of cells, organelles and the electron transport chain to automatically oxidize Co Q10. This process rapidly releases large amounts of free radicals which quickly damage cell / organelle structure and function and stops ATP (energy) generation by the electron transport chain. Brain and spinal cord cells are especially prone to this damage and can be irreparably damaged or even destroyed within minutes.
In conditions as explained above where CoQ10 produces damaging free radicals, Idebenone prevents the free radical damage and keeps relatively normal cell ATP levels. CoQ10 has excellent functions but in low oxygen conditions it turns negative producing free radicals but Idebenone does not have this negative side.
Along with producing over 90% of all cellular ATP, mitochondria are also generally the richest sites in Co Q10. Mitochondrial DNA (mtDNA) exists in the “heart of the fiery furnace” where electron “sparks” are constantly leaking as ATP is produced in the electron transport chain. This makes mtDNA more prone to free radical electron damage than is the DNA in our cell nuclei. Also the repair capacity of mtDNA is much less than that of our cell nucleus DNA. Consequently, over the course of a lifetime our mtDNA becomes ever more damaged and the mitochondria becomes ineffective at energy generation.
The cells that are most susceptible to mitochondrial energy depletion with advancing age are the brain, skeletal muscle and heart muscle cells. Idebenone thus offers a prime anti-aging effect serving as a powerful mitochondrial free radical quencher, lessening the ever-increasing mtDNA damage that occurs with age plus keeping energy production high, even under low oxygen conditions.
A variety of studies using brain cells have shown the ability of Idebenone to enhance brain structure and function. Other studies have demonstrated Idebenone’s enhancement of serotonin production and the cellular uptake of the amino-acid precursor tyrosine and cholinergic nerve function, which helps learning ability even under low oxygen conditions.
It also enhances a key part of memory formation and consolidation and restores glucose utilization (brain fuel) and ATP (energy) production in poor brain blood flow conditions. Idebenone has been shown to enhance general cerebral metabolism, lessen the damage from strokes and it is being used to treat Alzheimer’s and other dementias.
As we age or get older, blood flow to our organs diminishes due to arteriosclerosis and a less efficient heart pumping. This reduces oxygen and therefore reduces energy production, which is needed for repair and a normal functioning of the organ cells. Over time the effect of free radical damage accumulates leaving ever more dead, dying or dysfunctional cells within organs. Once a critical threshold is reached, that organ will fail.
Idebenone protects organs in many ways working against low oxygen levels and poor blood flow damage whilst enhancing ATP energy production.
Idebenone is a more powerful antioxidant than Co Q10 plus some studies have shown it as a free radical quencher within brain cells up to 100 times more effective than Vitamin E or Vinpocetine.
15 years ago a study resulted in showing that Idebenone was dramatically more effective than Co Q10 at preserving liver tissue under conditions identical to that endured by whole livers “harvested” and stored (briefly) before transplant to another person. The study recommended using Idebenone to increase the transplant viability of human livers donated for organ transplant.
In the human brain there are two main excitatory amino acid neurotransmitters -glutamic acid and aspartic acid. Under certain conditions like stroke, excessive amounts of excitatory amino acids accumulate in the fluid surrounding brain cells, causing free radical damage and even death to nerve cells.
Excitatory amino acid toxicity is partly responsible for the neuro-toxicity of the recreational drug “Ecstasy or MDMA” and studies conducted over the last 40 years have shown that excessive dietary intake of excitatory amino acids may also damage brain structure and function especially in children. The two main culprits for this are the flavor enhancer monosodium glutamate (MSG) and the artificial sweetener aspartame. Idebenone has shown dramatic protective effects against such toxicity.
Consult a Medical Professional
Consult a medical professional for the appropriate dosage recommendations as Idebenone is useful for a plethora of different conditions.
Using 45mg tablets daily dosages could vary depending on the condition. Healthy individuals wishing to enhance cognitive enhancement would use perhaps 2 or 3 tablets.Stroke victims wishing to improve memory, emotional or speech disturbances, Alzheimer’s and cerebrovascular dementia patients and for those preparing for major surgery, especially brain, heart, liver or kidney (synergizes well with Hydergine) all could use between 4 and 6 tablets. People with heart problems like cardiomyopathy, ischemic heart disease, congestive heart failure may choose between 3 to 6 tablets and those with myelination problems like multiple sclerosis the same applies. Those wanting to increase their general energy levels usually 2 or 3 tablets suffice.
Consult with your medical professional before taking.
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- Intermediate-dose idebenone and quality of life in Friedreich ataxia. – Read Full Article
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