Businessmen and women in Japan are clamouring over a potent vasodilator nootropic that advances mental clarity.
This latest of commercially available variations of ergot preparations is called Nicergoline. (There are three ergot preparations which are all related, each having differing strengths of reaction and very differing effects.)
Nicergoline’s reputation in Japan may be due in part because Japan is home to many of its clinical trials.
How does Nicergoline Work?
Nicergoline is an ergot alkaloid derivative. It induces vasodilation and increases arterial blood flow. That means brain cells are stimulated to uptake and utilize oxygen and glucose. It has neurotrophic and antioxidant properties.
Nicergoline has therapeutic value and potential in several disorders.
The therapeutic benefit of Nicergoline in the treatment of Alzheimer’s disease has been established with up to 89% of Alzheimer’s patients showing improvement in cognition and behavior even after as little as 2 months of treatment. Improvement is apparent and most patients maintained improvements after 12 months.
Concomitant neurophysiological changes in the brain indicate (after only 4-8 weeks’ treatment) improved vigilance and information processing.
Not only does Nicergoline improve mental clarity, but clinical trials confirm that it also improves blood circulation in the lungs and limbs and that blood platelet aggregation is inhibited. Though it does not affect arterial tension, it may gradually lower the arterial tension in patients who suffer from hypertension.
Benefits of Nicergoline Sermion
A Japanese clinical study on rats showed that Nicergoline increased nerve growth factor in the brains of aged animals, but showed no statistical affect on the brains of young animals.
Further studies indicate that Nicergoline enhances glutamate re-uptake and protects the brain from ischaemia (lack of blood flow). It presents as a mild stimulant and enhancer with long-term protection against brain disorders caused by deprivation of blood, glucose or oxygen.
We now understand that brain protection and enhancement is an important factor for anti-aging medicine and successful longevity.
Bernd Saletu, et al, “Nicergoline in senile dementia of Alzheimer type and multi-infarct dementia: A double blind, placebo controlled, clinical and EEG/ERP mapping study.” Pharmacia & Upjohn Nicergoline drug insert, Pharmacia & Upjohn, October 2000.
Asai S, Zhao H, Yama****a A, Jike T, Kunimatsu T, Nagata T, Kohno T, Ishikawa K, “Nicergoline enhances glutamate re-uptake and protects against brain damage in rat global brain ischaemia.” European Journal Pharmacology 1999 Nov 3: 3;383(3):267-74.
Takeshi N, Nobuhiko S, Shoei F, Ichiro A, Yukitsuka K, “Repeated injections of nicergoline increase the nerve growth factor level in the aged rat brain.” Japanese Journal Pharmacology, 76 (3), 321-323 (1998).
Iliff L, DuBoulay GH, Marshall J, et al, “Effect of nicergoline on cerebral blood flow.” Journal Neurol. Neurosurg. Psychiatry, 1977, 40:746-7.
Nicergoline Helps Treat:
Join the Japanese business community and experience the benefits of Nicergoline for yourself.