Organic brain syndrome (OBS) is a general term used to describe decreased mental function. Today, OBS is more commonly known as neurocognitive disorder. OBS  results chiefly from physical changes in the brain structure and is characterized especially by impaired cognition. Furthermore, OBS or neurocognitive disorder, refers to a brain dysfunction that is not attributable to a specific disease like Alzheimer’s or dementia.

Neurocognitive disorders or OBS, most commonly occur in older adults, but they may also affect younger people as well.   Reduced mental function may include:

  • Problems with memory
  • Changes in behavior
  • Difficulty understanding language
  • Trouble performing daily activities

Neurocognitive disorders can also develop as a result of brain trauma or substance abuse.  Healthcare providers can usually determine the underlying cause of neurocognitive disorders based on the reported symptoms and the results of diagnostic tests.  The cause and severity of neurocognitive disorders can help healthcare providers determine the best course of treatment.

Screen Shot 2016-10-12 at 7.19.28 AMWhat are some symptoms people may experience:

  • Memory loss
  • Confusion
  • Anxiety

Other symptoms may include:

  • Headaches, especially in those with a concussion or traumatic brain injury
  • Inability to concentrate or focus
  • Short-term memory loss
  • Trouble performing routine tasks, such as driving
  • Difficulty walking and balancing
  • Changes in vision

In those under 60 years of age, neurocognitive disorders are more likely to occur after an infection or injury. Non-degenerative conditions that may cause NDs include: concussion, traumatic brain injury that causes bleeding in the brain, blood clots, meningitis, encephalitis, septicaemia, vitamin deficiency and drug or alcohol abuse.  However, you’re also more likely to develop neurocognitive disorders if you:

  • Are over age 60
  • Have a cardiovascular disorder
  • Have diabetes
  • Abuse alcohol or drugs
  • Participate in sports with a high risk of head trauma, such as football and rugby

How Oxiracetam Combats OBS or Neurocognitive Disorders

Test results show that Oxiracetam enhances neurological processing in the brain, especially when it comes to neurotransmission. Oxiracetam supports long-term potentiation (LTP) which is a molecular episode in the brain crucial to learning and memory.

LTP is a stage when neurons are hyper-active following mental stimulation. The introduction of Oxiracetam supports glutamate neurotransmission. By increasing activity of the enzyme choline-acetyltransferase (ChAT), Oxiracetam multiplies acetylcholine production. This improves neuron connections.  Oxiracetam helps:

  • Brain Optimization: Oxiracetam improves cognition, memory, sensory perception and reflexes.
  • Neurotransmitters: Oxiracetam enhances ChAt which is critical for encoding new memories, reasoning and neuroplasticity.
  • Brain energy: Oxiracetam modulates AMPA-receptors in your brain, providing a stimulant-effect by influencing glutamate receptors.

In conclusion, Oxiracetam is used to boost short and long-term memory, eliminate brain fog, improve attention and focus, and the ability to learn.


  1. “Activity of Oxiracetam in patients with organic brain syndrome: a neuropsychological study”. – Moglia A, Sinforiani E, Zandrini C, Gualtieri S, Corsico R, Arrigo A. (June 1984) Clinical Neuropharmacology, New York.
  2. “Effectiveness of Oxiracetam therapy in the treatment of cognitive deficiencies secondary to primary degenerative dementia. – Rozzini R1, Zanetti O, Bianchetti A. (April 1992) US National Library of Medicine.
  3. “Organic Brain Syndrome”. – Lydia Krause; Timothy J. Legg PhD (2016).


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