Adrafinil —also known as Olmifon is a well-known nootropic or smart drug.  It is also a pro-drug to Modafinil.  This means that Adrafinil metabolizes in the liver to Modafinil.  As a result, it does not create hyperactivity in the body but increases your level of alertness and wakefulness.

This prodrug is also known as CRL-40028.  There are similar smart drugs or nootropics such as Verapamil, Butorphanol, Ketorolac Ophthalmic and Nystatin.  The world Anti-Doping Agency (WADA) has classified Adrafinil as a nonspecific stimulant and it is banned by WADA.

Between 600-1200 mg daily is the recommended dosage, taken orally.  However, it’s usually best to begin using Adrafinil at the lowest possible dose that you feel comfortable with until you see how your body reacts to it.

Best Time to Take Adrafinil

The best time to take Adrafinil is in the morning on an empty stomach because of the intense alertness that it creates.  It wakes you up and keeps you awake all day long.  As one becomes accustomed to it, they may prefer to split their dosage and take half upon waking and the rest before lunch time.  However, we don’t recommend taking it in the late afternoon or evening as it may well keep you awake all night.

How Long Does It Take to Work?

For most people, Adrafinil kicks in between 60 and 90 minutes after taking it.  That’s because it takes time to be absorbed in your body and metabolized by your liver.

Typically, it reaches a peak 2 to 4 hours after ingestion.  Therefore, you’ll likely feel your most alert and razor focused 2 to 4 hours after taking it.  This means that if you are planning on using it to help you study or for optimal in-class focus, you should probably take it 1 or 2 hours before hand.

How Long Does Adrafinil Last?

Although research has shown that the Adrafinil half-life is 1 hour in humans, this could be a little misleading.  Since it’s metabolized in the liver,it converts into modafinil, and the half-life of modafinil is 15 hours.  Therefore, you could feel the therapeutic effects of Adrafinil all day long just from one dose.


Because Adrafinil is stressful on the liver, and because you don’t want to build up a resistance to its effects, it should not be taken for extended periods of uninterrupted time.  Rather than that, consider cycling it.

For example, you could use it 3 times per week for two weeks, followed by one week off. After one week off, take it 3 times a week for one week, then two weeks off and repeat.

In any case, you should not take Adrafinil for any more than 5 months in a row.

The Scientific Breakdown on Adrafinil

What Exactly Is It?

Since Adrafinil is a synthetic substance comprised of diphenylmethyl sulfinyl-2 acetohydroxamic acid, it’s not natural nor is it found in nature.  These compounds has been frequently used to promote wakefulness, focus, and alertness.  It’s known as aeurgregoric agent. Olmifon was the original brand name.

How Does Adrafinil Work?

Although the precise mechanism of this prodrug is a bit of a mystery, it appears to mimic the chemical response of our body in “fight or flight” mode. It increases the body’s hypocretin production –a neurotransmitter that creates that feeling of alertness. For example, narcolepsy is thought to be caused by a lack of this neurotransmitter.

WhileAdrafinil raises the levels of hypocretin, it also promotes the production of other hormones and neurotransmitters, such as dopamine, norepinephrine and histamine. Of course, this affects your mental and physical energy levels.

Adrafinil also helps modulate Glutamate receptors.  This is one of the reasons why people use this nootropic for improving their cognitive functionality. Essentially, glutamate improves memory, neuronal communication and cognitive performance. Adrafinil inhibits the breakdown of this essential amino acid.

Side Effects

Although there are few negative side effects, there are some to take into consideration. Some have experienced headaches, dizziness or stomach problems like nausea or discomfort. And, with extended use, you could be putting your liver in danger. Because it causes a buildup of enzymes in the liver, used for extended periods,you risk reducing the function of your liver.

We recommend taking Liver Detox, which contains milk thistle among other ingredients to support liver when taking Adrafinil.
Also Read: More Benefits of Milk Thistle

Who Can Benefit from Using Adrafinil?

It’s mostly students, looking for a burst of focus and wakefulness to stay on top of their studies who appreciate the effects of Adrafinil. But, it’s also helpful for those who want to stay awake on shift work or those who work at night and need to be alert.

Since it has been banned by WADA, this smart drug is not recommended for athletes.

Common Stacks

Noopept And Adrafinil Stack

This stack is for people who are looking for wakefulness, memory, and enhanced focus.  Noopept and Adrafinil work great in tandem with each other.

Take 10-30 mg of Noopept 3 times daily. Take 150 mg of Adrafinil in the morning with the first dose of Noopept.

It is highly recommended that you don’t take any additional Adrafinil for the rest of the day as this could disrupt your sleep.

Adrafinil and Liver Detox (Milk Thistle) Stack

Adrafinil is the only effective stimulant you can get without doctor’s prescription.  However, it is a bit harsh on your Liver.  To experience better results and safety, take Adrafinil with Liver Detox (Milk Thistle)

Take 1  capsule of Adrafinil and one capsule of Liver detox with breakfast in the morning. Adrafinil promotes wakefulness, while liver detox protects liver and detoxifies the body. You can buy them together in Energy Bundle and save 10%.

Find out if Adrafinil is for you.  It may not be for everyone.  Although you can experience periods of great focus, you may also experience some negative side effects like headaches or dizziness.  So, if this is your first time with Adrafinil, take it easy.  Test the waters before diving in.

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