As a follow up to our post on What Alcohol Does To Your Brain, we wanted to re-publish for our readers and subscribers what the experience is of those Nootropics devotees are posting on forums like and other forums about their experiences with alcohol intake while taking brain supplements.

Many of the smart drugs have the effect of making you feel more inebriated with less intake which may or may not be a good thing.  On the one hand you may reach the point where you want to stop drinking earlier in the evening and consequently be doing you liver a favour and reducing your chances of a hangover in the morning.  However, if the occasion is making it difficult to realize when you’ve gone past the close, you could wake up with the wost hang over ever.

Piracetam and alcohol are contraindicated mainly because both are GABAnergic agonists. They both excite that inhibitory neurotransmitter/amino acid that mellows us out. No wonder it makes you a cheaper drunk! “

“If you’re looking for a supp that works well with alcohol, try sulbutiamine. Best there is, in my opinion. Some have found that it keeps energy levels up and prevents like 90% of the damage and hangover.Stay away from the ‘racetams + alcohol.”

“Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task.
Neuropsychopharmacol Biol Psychiatry (Progress in neuro-psychopharmacology & biological psychiatry.) 2005 Jul; 29(6): 928-35 ISSN: 0278-5846”

“I would say based off of the inherent neuroprotective properties of many of these substances, you may be better off using nootropics before a night of drinking. It may not prevent you from getting drunk but it may make the whole ordeal easier on your brain.

Of course the liver will still feel the brunt of the damage from a night of heavy drinking. There are non-nootropic supplements which can alleviate some of the burden on that organ (through various ways), but alcohol in excess will do damage regardless of the precautions taken.”

“personally I do not like to mess up an expensive nootropic stack head with some ethanol beverages. It seems like a waste of money. Kind of like washing down your smart pills with a stupid drink.

I have noticed with piracetam that people report getting far too fast of a drunk on. It does wear off faster it seems, I guess due to increased fluid flow in the brain. The problem is not noticed as much with Aniracetam for some reason.”


Well, after reading these posts it is the opinion of this writer that it doesn’t make a lot of sense to drink alcohol if you are supplementing with smart pills or nootropics.  There isn’t any danger in it per se, except the danger that already inherently exists with the strain put on your liver and the risk for a hangover and a wasted day following the night of.

Share your experiences with us – help others gain insight in what to expect


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