- Noopept For Memory and Cognition
- Noopept – A Peptide Nootropic
- History of Noopept
- Benefits of Noopept
- Neuroprotection with Noopept
- How It Works
- Noopept Dosage
- Noopept Stacking Advise
- Is Noopept Good for Brain Fog?
- Safety of Noopept
- Side Effects of Noopept
- Mode of Action
- Legal Status of Noopept
Noopept For Memory and Cognition
It has been found to improve memory, learning capacity, focus and concentration.
- Promotes Cognitive Enhancement and Memory
- Mild Psycho-stimulant and Anxiolytic Effect
- Exhibits Significant Neuroprotective Effect
This supplement is also important for supporting overall brain health. Noopept is actually considered a neuroprotectant, meaning that it has the ability to help protect the neurons in the brain from damage.
Noopept – A Peptide Nootropic
Noopept is a peptide nootropic promoted worldwide as a nootropic and it is sold in the U.S. as a legal dietary supplement. Noopept is not from the racetam family but it is generally grouped together in the same category because it shares similar mechanisms of action with the racetam family. It is growing in popularity due to its effectiveness as a cognitive enhancing compound and because its active dose range is between 10mg to 30mg, which is much lower than compounds that offer similar effects such as the racetams. When compared to the traditional racetams, Noopept has been found to be, according to studies, 1000 times more potent than the prototypical racetam nootropic, piracetam.
Noopept is one of the strongest nootropics available on the market today. It provides a boost to overall cognition and has a slight psychostimulatory effect. What makes Noopept a unique nootropic is that its effects are felt almost immediately after ingestion.
Studies show that Noopept has high neuroprotective properties. The stimulation of the neurons caused by this health supplement prevents oxidative damage and death of cells in the human brain, due to aging. Many patients dealing with cognitive impairment regularly can benefit from a regular dosage of Noopept to prevent further dissociative cognitive functions. Noopept has been shown to increase two very special proteins in the body, namely, NGF (Nerve Growth Factor) and BDNF (Brain-Derived Neurotrophic Factor). While NGF is involved in the growth, maintenance, and survival of nerve cells, including brain cells; BDNF protein in the brain can contribute significantly to long-term memory improvements.
History of Noopept
Noopept is a brand name for a smart drug that was developed in the 1970s. It was developed by a Russian pharmaceutical company, and is currently a prescription drug in Russia. In 1995, a patent application was filed in the United States. However, the FDA has not yet approved its use. The European Medicines Agency has not yet approved its use as well. This Noopept drug was developed and patented in Russia. It has been intensely researched since it has many benefits and very little side effects. Researchers in Russia consider Noopept to be somewhere between a thousand to five thousand more potent than its original cousin, Piracetam. Many studies have been completed in investigating the potential to reduce or even eliminate the degenerative neurological conditions and in addition to boost cognitive abilities in healthy people. Noopept was developed in the 1970’s by a company called JSC Lekko. Doctors in Russia and neighboring countries to treat anxiety, stress, and degenerative brain conditions.
Benefits of Noopept
Memory, Learning, and Recall: Noopept increasing one’s memory, learning abilities and speed of recall. It appears to be especially effective regarding long-term memory. Problem solving skills are also said to improve due to an increase in acetylcholine. Studies have shown that psychostimulants like this nootropic can provide an effective treatment for attention deficit hyperactivity disorder (ADHD).
Neuroprotective: Noopept acts as an antioxidant, it helps to detoxify the brain. Brain cell damage is reduced, preventing cell death. Nerve growth is also increased, leading to better overall brain health. It may be possible to repair damaged cells associated with Alzheimer’s and other related cognitive disorders with noopept.
Increased levels of NGF: NGF (Nerve Growth Factor) is a unique protein in the body that is involved in the growth, maintenance, and survival of nerve cells, including brain cells. NGF is also considered to be a key player in neurogenesis, your body’s ability to create new cells.
Increased levels of BDNF: BDNF (Brain-Derived Neurotrophic Factor) are chemicals in the brain responsible for the creation of new brain cells, and they promote the health of neurons, dendrites, and synapses. By taking Noopept you enhance the level of BDNF in the brain. Over time, an increase in this brain chemical can result in enhanced long-term cognitive health.
Improves Communication between Brain Hemispheres: Noopept enhances the development of connections and growth of new synapses that connect the left and right hemispheres of the brain improving communication between the two hemispheres. Some reports show improved quality of vision or sharper focus from the use of Noopept.
Neuroprotection with Noopept
The main goal in finding a nootropic with neuroprotective qualities is basically to protect the nervous system in the brain. Furthermore, it will also provide a great benefit to the neural functioning of the brain. In doing so, Noopept will clear any toxicity that is currently residing in the brain. An important activity of Noopept is to increase the vital protein BDNF which is a brain chemical that is responsible developing new brain cells. More importantly, it also improves the health of neurons, synapses and dendrites. For this reason, we can safely say that Noopept has long term brain health properties.
As is well known, both the right and left hemisphere of the brain have different functions. The human brain is divided in two hemispheres – left and right. This is called lateralization of the brain and refers to how some neural functions, or cognitive processes, will tend to more dominant in one hemisphere over another.
The damage to certain hemisphere helps us to understand how the resulting deficit will give us what the affected area is actually damage or not. The right side has effects on language and perception, while the left side brain damage will affect the ability to see low frequency, or big picture parts of an image. When a region of the brain, or an entire hemisphere is injured or destroyed, it’s function may very well be assumed by other regions of the brain.
How It Works
Noopept Powder is known to interact with glutamatergic system, modifying receptors to become more sensitive to glutamate, which plays a key role in cognitive processes such as memory formation and focus. Noopept has also been shown to increase nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).
Noopept also increases oxygen levels in the brain, providing a sense of clarity.
Since Noopept is so potent, only a small dose is needed. To supplement noopept, one should take 10 – 30 mg (divided into 2 or 3 doses) everyday for up to 56 days at a time with extended breaks in between each period of usage. The maximum daily dosage should be no more than 10 mg three times daily.
For 1st time users, we recommend starting with the minimum effective dose, with careful observation, before increasing dosage. Each person should determine their own optimum dosage.
The manufacturer of Noopept recommends taking dosages ranging from 10 – 30mg for cognitive deficiency, but for enhancement the optimal dose is unknown. However, Noopept is over 1000 x more potent than Piracetam. This is important because if you have used Piracetam and you have experienced the benefits of Piracetam, then using Noopept which is more potent pill will definitely give you a brain boost. Furthermore, it has been shown that over Piracetam, Noopept is more permeable and shows increased blood-brain barrier permeability. We recommend that you take Noopept with Alpha GPC, a Choline. While some users report benefits at even 15mg daily dosage, which is at the mid range, due to its slight stimulatory effects, we recommend that you do not take it in the evening or before going to bed. Noopept is known to be water soluble and has a bioavailability of around 10%.
Do not take Noopept late in the evening as its energizing effects may interfere with sleep.
Noopept Stacking Advise
Noopept can be taken alone but also does very well in nootropic stacks for synergistic benefits.
Noopept, Piracetam, and Alpha GPC Stack
Typical Noopept stacks will include a choline source such as Alpha GPC and even the mood-enhancing Centrophenoxine. You may want to include Piracetam to potentiate noopept’s effects. Piracetam works on acetylcholine and Noopept works on glutamate. The two supplements taken together therefore boosts functionality of both transmitters resulting in a tremendous boost to a variety of cognitive processes. Adding a choline supplement to the stack makes the piracetam more effective and helps to hold off headaches reported by some initial-stage Noopept users.
Noopept, Aniracetam, Sulbutiamine Stack
You can stack Noopept with Aniracetam and Sulbutamine to potentiate its cognitive effects, improve mood and at the same time to reduce anxiety. These effects on mood and anxiety should also indirectly lead to improved creativity and mental performance due to the relaxed mind state.
Noopept appears to be very safe in stacking with other members of the racetam family or similar nootropics. There are limited reports of serious drug contraindications however, it is recommended to use caution and due diligence. Noopept is best stacked with a Choline source, for example, Centrophenoxine or Alpha GPC. The choline would be a great complement in relieving common side effects and enhancing the effects of Noopept. Furthermore, Noopept is also very popular to be taken alone.
Keep in mind that all nootropics should be cycled to avoid building up a tolerance to it.
Is Noopept Good for Brain Fog?
With its neuroprotective qualities, Noopept protects the neurons in the brain against damage and stress caused by oxidation. This would be similar to anti-oxidants. The positive effects on both oxygen and glucose levels do wonders for the increase in mental energy and focus, so that both concentration and attention span gives a sense of clarity which many have reported as clearing of the “brain fog”. These effects have added to the popularity of the drug and many users have given it the description of having “recall” capabilities.
Its popularity with concentration and focus for prolonged periods of time seem to correlate with its ability to provide focus, concentration and increased productivity, including the ability of users to manage and control stress levels and anxiety.
Safety of Noopept
Noopept is safe for consumption and is non-toxic, just like the other racetams family members. What this means that is has little or no side effects, which is different from one person to another. Tolerance is personal. The fact that it is non-toxic to our bodily organs means that there are no byproducts from the immunological system in our body, or that there are no mutagenic components upon consumption. While you cannot overdose on these racetams, you can definitely experience a terrible hangover or headaches or nausea. It is therefore recommended that you follow the directed dosages as per each supplier.
One of the main cautions we would highlight is that if you suffer from either high blood pressure or hypertension, you would not want to overdose or even go over the recommended dosage. It is highly unlikely that a higher dosage will result in any serious bodily harm. However, keep this product very far away from children, since it is recommended for adults only and for research purposes only.
Side Effects of Noopept
Noopept is well-tolerated in healthy adults and has very low risk of side effects when used according to recommendations. High doses of noopept (above 30 mg) can cause short-term memory loss, brain fog, headache, and issues sleeping. To combat headaches, try taking Noopept in a stack with a choline supplement like our Alpha GPC or Centrophenoxine.
If you are taking other medications, ask your doctor if there will be any significant interactions. Currently, there are no dangerous interactions reported. However, this does not exclude the possibility.
Mode of Action
Noopept has many modes of action and the one is anti-oxidation, which protects neurons from apoptosis. Another mechanism of action includes inhibiting glutamate neurotoxicity (which often leads to degenerative diseases like Alzheimer’s disease). The most important mode of action is on neuroplasticity, which improves learning and memory.
As described above, Noopept is fast-acting and more potent and effective than other racetams. The most basic mechanism of action for this compound is that it interacts with the Glutamatergic system, modifying receptors to become more sensitive to glutamate. This qualifies Noopept to play a key role in the cognitive process, including memory formations and concentration. Noopept has also been shown to increase NGF (nerve growth factor) and BDNF (brain-derived Neurotrophic factor.
Since the workings of Noopept affect the Glutamatergic system, it is used for cognitive support and neuroprotective health, which helps in keeping the brain healthy. Furthermore, Noopept helps protect neurons from apoptosis, improves inter-communication between synapses, and most importantly, it helps in preventing or slowing down oxidative stress. In doing so, the important mode of action is neuroplasticity, which helps improve learning and memory. This is why Noopept is often taken by people with onset of Alzheimer’s who have experienced some type of degenerative disease.
Legal Status of Noopept
Noopept is an unscheduled substance in the United States. It is legal for anyone to purchase and consume the drug for personal use. It can be imported in most countries in Europe, Canada and Great Britain. Most countries allow importation of Noopept for personal consumption, and commercial importation of the drug is strictly important. It is easily available online and can be ordered for personal consumption. It is very unlikely to find Noopept in retails stores, so the internet is the place to buy, and you are allowed to buy, possess and use it.
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- Noopept normalizes parameters of the incretin system in rats with experimental diabetes. – Read Full Article
- Comparative activity of proline-containing dipeptide noopept and inhibitor of dipeptidyl peptidase-4 sitagliptin in a rat model of developing diabetes. – Read Full Article
- Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. – Read Full Article
- Neuroprotective and nootropic drug noopept rescues Î±-synuclein amyloid cytotoxicity. – Read Full Article
- Nootropic dipeptide noopept enhances inhibitory synaptic transmission in the hippocampus. – Read Full Article
- Noopept in the treatment of mild cognitive impairment in patients with stroke. – Read Full Article
- Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells. – Read Full Article
- The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model. – Read Full Article
- Anti-inflammatory properties of noopept. – Read Full Article
- Early postnatal effects of noopept and piracetam on declarative and procedural memory of adult male and female rats. – Read Full Article