What is Adrafinil?

What is Adrafinil? – Discovered by the French

Why Adrafinil? But more importantly, What Is Adrafinil? Olmifon/Adrafinil was originally created in the 1970s in France by Louis Lafon Laboratories as one of the sleep medications used to treat sleep disorders. It is a novel pharmaceutical because of its unique behavior-activating effects and because it lacks the undesirable side effects that other stimulants exhibit. There is also an absence of peripheral sympathomimetic effects in subjects to treat with it. (In other words, there’s no crash, like with a Ritalin comedown.)

Nootropic or Eugeroic Drugs

Most of the studies published on Olmifon/Adrafinil are in French. Jouvet was first to introduce the term “eugregorique” (eurgregoric or eugeroic in English) for this type of arousal-producing agent. Studies show that Adrafinil (the Modafinil precursor) has clinical efficacy in promoting vigilance and enhancing mood in the elderly. Olmifon/Adrafinil has become popular to a larger, nonscientific audience as a nootropic agent or “nootriment”.

Modafinil Supplement for Sleep Apnea

Literature published on Modafinil (the primary metabolite of Adrafinil) focuses on the potential application of Modafinil in the treatment of sleep disorders and Modafinil (Provigil) has received regulatory approval for the treatment of narcolepsy in the United States. Since the types of clinical trials differ for Adrafinil, it’s not clear whether Adrafinil effectively replaces Modafinil or whether the two are uniquely invaluable for different applications. Adrafinil is one of the milder of the two and requires a larger dose to reach the same potency as Modafinil.

What are Smart Drugs?

“Smart Drugs” is the name given to nootropics that work on the brain. Nootropics are a group of supplements that combine synthetic ingredients and inhibitors to increase circulation and chemical reactions in the brain which enable users to focus more sharply, think faster and retrieve memories more easily.

How to Buy Adrafinil

Many people, from all walks of life have embraced Adrafinil as their go-to to stay mentally active and alert. Thanks to the Internet, we can now buy Adrafinil in US by purchasing it online and having it shipped. Its memory-enhancing properties are being applied to mitigate memory decline in the elderly and those with dementia and Alzheimer’s disease. Students buy Adrafinil to learn better. Programmers and techies buy Adrafinil to perform better and be smarter. Shift-workers buy Adrafinil to stay awake and focused during a long night-shift.


When it first was created, Adrafinil was known as Olmifon or CRL-40028. Though it has often been confused with Modafinil, they are not the same. Adrafinil is a Modafinil precursor. Modafinil metabolism happens in the liver, which is the reason for the Adrafinil liver rumors going around.

Liver Concerns

Because the liver must produce enzymes to perform the Modafinil metabolism, there are concerns that taking Adrafinil stresses the liver over time, though there are no cases of this happening. (Of course, if one already has liver issues, they should take this into consideration and talk to their doctor before using it.)

Adrafinil (Olmifon) is classified as a non-specific stimulant and has been banned by the Word Anti-Doping Agency (WADA) because using it would give competing athletes an unfair advantage.

Similar nootropics are: Verapamil, Ketorolac Ophthalmic, Butorphanol and Nystatin.

Adrafinil Dosage

The usual capsule of Adrafinil dosage is 300 mg which will last several hours (up to 10 hours for some people). It also comes in Adrafinil powder form. There is a slight tolerance in taking it regularly, so dosage varies between 600-1200 mg daily, taken orally. How much Adrafinil to take depends on your personal tolerance and how it affects you. It is best to start with the usual capsule Adrafinil dosage of 300 mg, unless otherwise prescribed by a doctor.

How to Use Adrafinil

What is Adrafinil?, Adrafinil, Antiaging Central

Adrafinil experiences differ widely. The more you take, the longer it lasts, so the best time to take it is in the early morning on an empty stomach, whether in Adrafinil powder form or Adrafinil capsules. Adrafinil powder is water-soluble and can be mixed in juice or water.

Water-Soluble Powder

If taking capsules, the Adrafinil capsules can be opened to halve the dose and taken with liquid. Another alternative is to take one full capsule and another half of the Adrafinil powder out of the capsule. This way, you can tailor your dose to how much Adrafinil to take and decide how to use Adrafinil.

How Long Does Adrafinil Take to Work?

Because the Adrafinil to Modafinil metabolism happens in the liver, the Adrafinil onset takes anywhere from one hour to two hours to feel the effects. Even then, the effects are very gentle although you’ll feel a dramatic increase of focus, peaking 3 to 4 hours in.

An Adrafinil High?

Adrafinil is so gentle that sometimes the Adrafinil onset is not even noticeable and there really is no Adrafinil high. –Although you may feel happier just because the dopamine receptors are liberated. Think of Adrafinil as a Modafinil supplement as it is a Modafinil precursor in fact.

Looking for Higher Exam Scores?

While Adrafinil may not get you high, it may get you higher scores on exams with less effort and no cheating involved. When facing an exam or using Adrafinil for in-class focus, the ideal time to administer the drug is probably 3 hours prior to the targeted time of your exam or requirement for intense focus. Depending on when that intense focus is needed most will determine how to use Adrafinil and how much Adrafinil powder to take. Although you can take Adrafinil with or without food, Adrafinil capsules are best taken on an empty stomach for faster delivery.

How Long Does Adrafinil Last?

Modafinil metabolism happens in the liver and the Modafinil half-life is 15 hours. Therefore, therapeutic effects of Adrafinil are felt all day long from only one dose in the early morning. In other words, we should consider that the Adrafinil half-life is the same as the Modafinil half life at equivalent dosages, once you decide how much Adrafinil to take. (200 mg of Modafinil is equal to approximately 300 mg of Adrafinil.)

Modafinil Cycling

The case with many nootropics is that they should not be taken uninterrupted over extended periods of time. The reason for this is that the body tends to build up a resistance to it so that an increase of the dosage is necessary to obtain the same results.

For example, Adrafinil can be cycled three days a week for two weeks on and two weeks off. As a nootriment, it should not be taken for more than five months in a row or it will lose its effectiveness. Because the Adrafinil to Modafinil conversion takes place in the liver, liver stress can be avoided by cycling the Adrafinil dosage.

Does Adrafinil Work Less Over Time?

Modafinil cycling will prevent your body from becoming immune to the effects as well as preventing Adrafinil side effects. Unlike other drugs, nootriments perform better after a break. If you require 900 mg Adrafinil to achieve the same results as the original 300 mg per day, you’re taking 3 times the normal dosage. That means your body has built up some serious resistance.

What is Adrafinil?

Adrafinil is a synthetic substance comprised of diphenyl methyl sulfinyl-2 acetohydroxamic acid. It is not found in the body nor in nature, but is a eugregoric agent, known in the past as Olmifon.

How Does Adrafinil Work? (And More About What is Adrafinil?)

We may not fully understand how Modafinil works but we do understand a little bit about what happens in our body in “fight or flight” mode.  So, how does Adrafinil work? –It appears to mimic the chemical response our body goes into during “fight or flight” by increasing the production of hypocretin in the body. (Hypocretin is a neurotransmitter responsible for vigilance. For instance, a lack of hypocretin in the brain can causes narcolepsy.)

The “Happy” Neurotransmitters

When levels of hypocretin are increased, it leads to the production of other hormones and neurotransmitters that affect our mental and physical energy levels. Neurotransmitters such as dopamine and norepinephrine and histamine help make us happy and motivated.

The chemical structure of Adrafinil is just like Modafinil with the addition of an OH (hydroxyl group) to the amide nitrogen, forming a hydroxylamine.

Part of the Adrafinil dose you take is converted to Modafinil, with the remainder metabolizing to modafinilic acid.

What are Smart Drugs?

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Another thing Adrafinil does is to modulate glutamate receptors which improves cognitive functionality. Sufficient glutamate (an amino acid) improves memory, creates better neuronal communication and enhances cognitive performance.  Adrafinil inhibits the breakdown of glutamate. Pretty smart, right?

How is Adrafinil Metabolized?

The Adrafinil to Modafinil conversion happens in the liver where a percentage of it turns into modafinilic acid or modafinil sulfone. This process forms a modified version of Modafinil nootropics.

Adrafinil Reviews:

Wiley Online Library reported the results of research that showed an impressive degree of consistency to indicate that the Modafinil prodrug, Adrafinil can be highly beneficial to treat patients that show deficits in vigilance, behavior, attention, and mood.

Israel et al.  Studied the effects of Adrafinil in 99 ambulatory patients aged 65 and older who had severe problems in vigilance affecting normal daily activities. In a double-blind placebo-controlled study, evaluations were made by general practitioners using a series of tests.

Positive Adrafinil Experiences

Results showed dramatic improvements on the Dynamic Intellect Scale measures of: confusion, concentration, attention, power of recall, vigilance, and fatigue. By day 45, there were improvements. Further improvement by day 90 as well. Patients in the Adrafinil Group also felt happier and more energized by the end of the three months with no Modafinil health risks and no withdrawals like a Ritalin comedown because Adrafinil is a non-addictive nootriment. Cerebral stimulants drugs, especially Modafinil nootropics and the Modafinil substitute, Adrafinil, prove themselves remarkably in improving the lives of elderly folks.

Clinical Tests

Kohler and Lubin examined the effects of the Modafinil prodrug, Adrafinil, in 304 patients, aged 45 to 88 years, with difficulties in attention-concentration, memory, anxiety, and inactivity. For three months, patients received 900 mg per day of Adrafinil (an Adrafinil megadose: 600 mg in the morning and 300 mg at noon).

Adrafinil Reviews

Adrafinil reviews in this clinical study showed improvements in attention, vigilance, and concentration.  There were also statistically significant improvements in measures of Zazzois Test, which measures vigilance and attention; the Derouesneis Scale, which assesses difficulties of normal daily life and Sungis Depression and Anxiety Scales.

With Adrafinil treatment, daily activities improved that reflected improved memory functions as well as autonomy. Depression and anxiety were greatly diminished and no “comedown” as with Ritalin comedown. All the Adrafinil experiences were positive.

Science of Nootropics

We can take advantage of the fact that science is advancing rapidly, discovering new brain health supplements and venturing into the unknown to find new solutions to old problems. Our brains, young or old can benefit from some of these discoveries, such as Adrafinil.

One reason Adrafinil vs Provigil is more popular is because you can have it without a prescription. Since there is no regulation, we can buy it legally, like any other supplement.

Side Effects of Adrafinil

The majority of Adrafinil experiences are very positive. It’s a truly potent modafinil supplement that you should take with discretion, like any other supplement. Once you have used it, you’ll know how much Adrafinil to take to suit your body chemistry.

To avoid over-dosing, take 300 mg per day three times per week, up to 900 mg Adrafinil per week. As with all cerebral stimulants drugs, it’s important to follow the manufacturer’s instructions to prevent modafinil health risks.


In answering the question of What Is Adrafinil, we need to look at the warnings. Do not consume a higher dosage than 400mg of Adrafinil daily. Consult your doctor before taking a higher Adrafinil dosage because it may elevate liver enzymes or cause side effects like increased anxiety, nausea, and sleeplessness.

Take extreme caution when using this drug as it is very strong and affects some of the most critical parts of the body. Several things can lead to negative side effects and the most important is the dosage. Follow the dosage and do not take any more than the recommended dose.

Although an Adrafinil megadose may provide you with extra effects, it’s only temporary. You may later experience dangerous side effects which can cause serious problems.

Bright-Eyed and Bushy-Tailed

Adrafinil reviews show that, when they take the recommended dose, it promotes alertness without feelings of stimulation and that Adrafinil side effects are almost non-existent when we avoid the Adrafinil megadose some are going to try.

A 300mg capsule (900 mg Adrafinil per week) works well when you need a boost. Just be sure to avoid taking it too late at night so it doesn’t interfere with your sleep. Taking it 90 minutes before wake-up (and returning to sleep) will allow for the Adrafinil onset to wake you up bright-eyed and bushy-tailed.

Does Provigil Show Up in Urine Drug Screen?

Adrafinil (What Is Adrafinil? – The Modafinil prodrug) eliminates through plasma and urine, though it seems to go faster through plasma. Since it is in both places, it is not difficult to detect. So, the answer to the question, “Does Provigil show up in urine drug screen?” is, “Yes.” Provigil also happens to be an unallowable substance by the WADA, so if you are an athlete who undergoes regular drug testing, you should not take an Adrafinil megadose before a competition. Even a Provigil recommends a dosage that the WADA test can detect.

Modafinil Headaches

Experiencing headaches, dizziness or stomach issues like nausea or discomfort is what some users have. Although Modafinil health risks are rare, they should take into consideration and if any of these symptoms show up, you should stop using Adrafinil immediately.

Depending on your needs and desired outcomes, you may experience periods of great focus and alertness, but you may also experience negative side effects such as headaches or dizziness. As with any modafinil substitute, start with the lowest recommended dosage and see how your body reacts. Make sure to use the best Adrafinil brand that’s dependable so you won’t have a bogus product.

Modafinil’s Many Names

What you have to know when talking about Provigil or Adrafinil is that they are Modafinil with new names and, in some cases, are a little different but having quite similar effects in the body. Provigil (brand name in the US for Modafinil) is interchangeably with Modafinil and the terminology “Provigil” online is often with Modafinil in brackets so that one would think they are both the same animal by another name.

Are All Smart Drugs Equal? (What Is Adrafinil?)

Provigil equals Modafinil which equals Armodafinil which equals Nuvigil which almost equals Olmifon, which equals Adrafinil. Adrafinil is a little bit different in that it is a prodrug/precursor/pro-derivative of Modafinil which is also Armodafinil/Nuvigil/Provigil. Adrafinil has the name Olmifon, except that Olmifon is going to be  discontinuing(Adrafinil was actually “discontinued in Sept 2011 for Modafinil”). Provigil is actually a Modafinil substitute or just another name for exactly the same product.

Olmifon/Adrafinil is not exactly Modafinil, so therefore, Provigil is not exactly Adrafinil. In some respects, they are alike. For instance, as with Adrafinil, long term use of Provigil can be into different cycles.

Armodafinil Vs Modafinil

Armodafinil has been selling as Nuvigil in the States  since 2007. It is a follow-up to Modafinil and an enantiomer of Modafinil with a slightly modified chemical structure which makes it more potent than other sleep medications. (Whether or not that’s a good thing depends on the individual’s reaction to nootropics. For some, this extra potency may mess up their sleep patterns.)

Specific effects can be associated with each of these drugs. So, which is better – Armodafinil vs Modafinil? Both effectively treat the same clinical conditions. Armodafinil requires a smaller dosage but Modafinil’s effects may be preferable for some users.

Different Reactions for Different People

Especially when it comes to using nootropics, every individual is a little different in their preferences and experiences. Different drugs can have very different reactions in different people. We should always keep that in mind and not compare ourselves with how others use nootropics or how much of a dosage they take. Potency is not the only factor but the total experience of using it.

Adrafinil Vs Provigil

Some satisfied customers are saying that the benefits pound-for-pound of Adrafinil vs Provigil is that no other drug holds a candle to Adrafinil. It’s very different from amphetamines and xanthenes which prevent sleepiness but cause hyperactivity – a very bad idea indeed.

Gentle Adrafinil diverts several Provigil or Modafinil health risks, saving your brain from all those brutal effects. It promotes wakefulness more naturally. Adrafinil vs Provigil improves your neurotransmitter communication, injecting you with positive mental energy. It doesn’t tend to interrupt sleep patterns for those sensitive to drugs as Provigil may do.

Adrafinil Vs Provigil: Effects

Both drugs are full with wakefulness and cognitive benefits, the difference is that Provigil lasts longer. The best way to take Provigil is as a supplement for being more productive, fighting jet lag and treating depression.

The way Provigil/Modafinil works in the brain is that it smoothly transitions in and out of the “zone”. This contrasts other drugs/ supplements that provide a huge spike of energy and then a crash right after the effect wears off. Though some have experienced Modafinil headaches, modafinil problems are rare with Adrafinil.

If you plotted a focus curve using Provigil, it would show a steady increase, plateau, then gradually decline. Adrafinil vs Provigil, on the other hand, is great for students, programmers and writers who want to sink their teeth into their work for a few hours and hit the sack when the effects begin to wane.

How Fast Does Provigil Work?

It takes between 25 minutes to 1 hour for Provigil to kick in. Based on experience, Provigil –the Modafinil substitute should keep you awake with positive mental triggers for about 10-12 hours from the moment it starts to activate, while Adrafinil gives you the same effect for about 7-8 hours, which is great for an “evening nootriment”. The Modafinil prodrug, Adrafinil has a design of a lighter version of Provigil.

New to Nootropics? (What Is Adrafinil?)

If you’re new to Smart Drugs, Adrafinil is a good place to start to get a feel for the eugeroic class of drugs. Although the typical dosage is 300 mg, many users may do as much as 1200 mg. The reason is that there is a slight build-up of tolerance to Adrafinil over time.

Modafinil Dosage

According to preference, Modafinil comes in tablet as well as powdered forms. They recommend a dosage in either case is 200 mg, take in the early morning on an empty stomach. (This is also the best way to take Provigil and the same as the Provigil recommended dosage.) With a larger dose, there is risk of side effects which include headaches, diarrhea or cramps. Exceeding the dose adds little value to your experience and is best to avoid.

Trial and Error

Some people prefer to take Provigil first thing in the morning, while others take it just before the start of a work shift for night-shifts. There is an observation that different nootropics affect people in different ways, according to age, gender, health, tolerance, etc. Trial and error is probably the best way to decide what’s best for your body for long term use of Provigil.

Tell Your Doctor if . . .

If you have had an allergic reaction from Modafinil, Armodafinil, Nuvigil, Olmifon or Adrafinil, avoid using Provigil. Ask a doctor for the best way to take Provigil. Provigil can cause skin irritations severe enough to go to a hospital. It is wise to stop taking this drug immediately if any of the following occur: skin rash, hives, blisters, peeling, mouth sores, fever, dark urine, breathing difficulties, yellowing of skin or eyes or swelling of the face.

Before long term use of Provigil, be sure to tell your doctor if you have angina, liver or kidney disease, a heart problem, a drug addiction, if you take blood pressure medication, or if you have recently had a heart attack.

Modafinil Vs Adrafinil

The metabolizing of Adrafinil into Modafinil takes place in vivo, though, functionally, they have identical pharmacological effects. The active metabolite of Adrafinil is Modafinil, but not all of it converts into Modafinil. Some converts into modafinilic acid. This means that, theoretically, Adrafinil is less potent than Modafinil. For the same effects as Modafinil, you are going to require more Adrafinil powder.

Unlike Modafinil, it takes time for Adrafinil’s metabolite to accumulate to active levels in the bloodstream so it goes to work more slowly — within 45-90 minutes when taken orally and on an empty stomach. This gives us a better understanding on how to answer the question, What Is Adrafinil?

Adrafinil Vs Modafinil (Legalities)

When it comes to legalities in the US, Modafinil is a prescription drug (Schedule IV) and it’s illegal to possess it in the US without a prescription. Prosecutions are rare. American purchase modafinil overseas; customs have parcels but legal actions have yet to take place.

On the other hand, Adrafinil vs Modafinil is unregulated in the US, which means you can sell it as a dietary supplement. Adrafinil is cheaper and more readily available, due to the legal risks associated with purchasing Modafinil online.

Let us know if you have any more questions concerning, What Is Adrafinil?

See Also:


Adrafinil Vs Modafinil Dosage

The Secret of the Successful

Adrafinil vs Modafinil reddit

Adrafinil: Active Ingredient is Modafinil

Categories: Supplements


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